Ticagrelor-Induced Prolongation of the QTc Interval

Ray, Avik and Najmi, Ahmad and Khandelwal, Gaurav and Sadasivam, Balakrishnan (2019) Ticagrelor-Induced Prolongation of the QTc Interval. Case Reports in Cardiology, 2019. pp. 1-4. ISSN 2090-6404

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Abstract

Background. Ticagrelor has been accepted as a class I antiplatelet agent in patients undergoing percutaneous coronary angioplasty (PTCA). There have been cases reported on ticagrelor being associated with various cardiac conduction defects. But there is no evidence of QTc prolongation associated with the drug as of yet. Case Presentation. A 64-year-old male who underwent PTCA was given ticagrelor. A baseline electrocardiogram (ECG) showed a QTc of 402 ms. He returned after 1.5 months with complaints of shortness of breath. An ECG revealed a prolonged QTc of 468 ms. Ticagrelor was discontinued in view of ticagrelor-induced dyspnea and the patient was started on clopidogrel. The other medications were kept unchanged. The patient returned after a month without any complaints. A follow-up ECG showed a reduced QTc of 425 ms. Conclusion. We present a case of ticagrelor-induced QTc prolongation. To our knowledge, this is the first case to be reported on the same. The Naranjo algorithm for causality assessment gave a total score of 6 indicating that the adverse drug reaction falls under the probable category.

Item Type: Article
Subjects: Universal Eprints > Medical Science
Depositing User: Managing Editor
Date Deposited: 18 Feb 2023 09:45
Last Modified: 09 May 2024 13:12
URI: http://journal.article2publish.com/id/eprint/763

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