Duodenal Pseudomelanosis: A Rare Incidental Endoscopic Finding of Undetermined Significance

Duodenal Pseudomelanosis (DP) is an extremely rare endoscopic finding which has been linked uncertainly to a spectra of disorders. It is characterised endoscopically by presence of speckled hyperpigmentation of duodenal and proximal jejunal mucosa. The underlying histology of the involved regions show pigment laden macrophages in the lamina propria of intestinal villi. The condition has been linked to hypertension, chronic kidney disease, heart failure, gastrointestinal bleeding, anemia, oral intake of iron supplements and sulphur containing diuretics, eosinophilic enteritis and some rare cases of gastrointestinal malignancies. The exact etiopathogenesis of DP remains unknown and so are its clinical implications and significance. In the near feature as more cases of this rare entity are acknowledged, its noteworthiness might get discovered.