Dilemmas in Grading Epidermoid Carcinoma: An Overview

Oral squamous cell carcinoma (OSCC) can be preceded by the appearance of lesions which have the potential either to develop into cancer or signal the development of cancer in the oral cavity. Oral squamous cell carcinoma is the 8th most common cancer worldwide, with a predisposition for low-income populations, and greater prevalence in older men, 90% being in the 45-year-age group. Histologic grading has been used as a prognostic factor and for clinical evaluation of OSCC for the past several decades. Simultaneously, there exists ongoing controversy surrounding the predictive significance of various grading classifications. Consequently, our article undertakes a comprehensive examination of diverse grading systems for oral squamous cell carcinoma and assesses their prognostic implications.