SYNTHESIS AND BIOLOGICAL ACTIVITIES EVALUATION OF NEW SUBSTITUTED 1,2,4,8-TETRAAZASPIRO[4.5]DEC-2-ENES

A new series of 1,2,4,8-tetraazaspiro[4.5]dec-2-enes containing 1,2,4-triazole, piperidine and sulfonamide moieties have been synthesized from the reaction of 4-piperidone benzoylhydrazones having 1-methyl, 1-benzyl, and 1-isopropyl groups with appropriate nitrilimines. The microanalysis and spectral data (IR, 1H NMR, 13C NMR and MS) of the synthesized compounds are in full agreement with their molecular structure. The microbial features of the synthesized compounds were studied by a known method. Some of titled compounds exhibited significant antimicrobial activity on several strains of microbes.