Synthesis and Potential Anti-Anxiety Activity of Some Novel Quinazolin-4 (3H)-One/Thione Derivatives

The present research work is to synthesize some new series of quinazoline-4-one/4-thione derivatives
by modifying the structures retaining the fundamental structural features for the biological activity and
screened for their anti-anxiety activity by different experimental animal models. A series of 7-chloro-3-
[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4(3H)-one/thione derivatives and 1-(7-chloro-
4-oxo/-2-phenylquinazoline-3-(4H-yl))-substituted urea derivatives were prepared and characterized
from different spectra and elemental analysis. The anti-anxiety activity was investigated by elevated
plus maze test, hole board test respectively. The physico-chemical and spectroscopic data confirmed
the synthesis of quinazoline derivatives. Five compounds (IIg, IIj, IIIg, IIIh and IIIj) showed good anti
anxiety activity as compared to diazepam and didnot show neurotoxicity in rotarod test. The
quinazoline derivatives obtained indicates that the methyl/methoxy group in phenyl hydrazine ring,
amine, urea and thiourea substitution at 3rd position of quinzoline ring are essential for anti-anxiety
activity. A further study is going on for in vitro study of the newly synthesised and pharmacologically
potent quinazoline molecules.