CHEMBAN, SAFVAN ALI and KAUR, LAKHVIR and SINGH, GURJEET and DHAWAN, RK and KAUR, NARINDER and KAUR, NAVJEET (2021) TECHNIQUES FOR ENHANCING THE SOLUBILITY OF POORLY WATER-SOLUBLE DRUGS: A COMPARATIVE REVIEW. Journal of International Research in Medical and Pharmaceutical Sciences, 16 (2). pp. 46-58.
Full text not available from this repository.Abstract
Reduced water solubility causes drugs to dissolve slowly and absorb poorly, leading to low bioavailability. Solubility is an important factor to consider during the design and research process because most medications are weakly acidic and weakly basic. Appropriate studies and techniques are required to improve drug solubility and thus bioavailability and therapeutic effects. This review briefly explores particle size reduction, inclusion complexes, co-solvency, microemulsion, spray drying, nanotechnology, and other solubility enhancement techniques, as well as a comparison study of techniques based on research study. In conclusion, even though all solubility enhancement techniques are effective and have the potential to improve solubility, they each have their own set of advantages and disadvantages. As a result, stating any technique is superior to another is unfeasible.
| Item Type: | Article |
|---|---|
| Subjects: | Universal Eprints > Medical Science |
| Depositing User: | Managing Editor |
| Date Deposited: | 02 Dec 2023 06:09 |
| Last Modified: | 02 Dec 2023 06:09 |
| URI: | http://journal.article2publish.com/id/eprint/3225 |
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