THE NEGATIVE EFFECT OF MERCURY IN COSMETICS ESPECIALLY IN BRAIN CELLS AND COLLAGEN TISSUE QUANTITY THAT RECOVERY WITH NANO-GOLD

The pre-clinical research has been done to get empirical date the real of negative effect of mercury that used in cosmetics (mercury face cream). This research used 24 animals Mus Musculus divided into 6 groups; Control group; Mercury group; Nanogold 5ppm; Nanogold 10 ppm; Nanogold 15ppm and Nanogold 20 ppm. After adaptation two weeks All animal treat by mercury face cream for a week, except control group. After this treatment, 4 class continuous by recovery with nanogold 5, 10, 15, and 20 ppm for 4 weeks. One group that call mercury group killed to investigate effect of mercury face cream. Mercury had cause damages of fibroblast and reduce collagen quantity in skin tissue at previous research. This research investigated haw impact mercury in face cream at brain cells and collagen quantity of brain tissue if mercury exposure in skin area. The treatment continuous with nano-gold face cream to recovery and reduce these damages. HE staining used to analysis brain cells condition and Van Gieson staining used to analysis collagen quantity. The conclusion that a week mercury exposure caused many damage of tissues including collagen tissue, brain cells and others connecting tissue in brain. Recovery for 4 weeks with nanogold at variance concentration (5, 10, 15, and 20 ppm) reduce brain damage, especially brain cells and collagen tissue step by step near normal condition. The role of concentration of nanogold was real. The increase nanogold concentration give recovery be better. The impact of this research nanogold sweet material to substitute mercury that very dangerous material in cosmetics. Nanogold in the future as the best material in cosmetics formulation.