BISPHENOL-A INDUCED DYSLIPIDEMIA AND HEPATIC STEATOSIS IN Channa Punctatus

The presence of endocrine disrupting compounds in the environment raises serious concern about their effects on humans and other living organisms. Bisphenol-A is a highly controversial endocrine disruptor that is ubiquitous in the environment. The large-scale production of Bisphenol-A and its subsequent release into the environment far exceeds its removal by natural processes. Within the body, Bisphenol-A’s agonistic and antagonistic attributes are known to disturb the action of several hormones and interfere with lipid homeostasis in several species. Liver is the major organ for lipid metabolism. Bisphenol-A exposure causes lipid accumulation in the liver. In this study we investigated the effects of 15 days and 30 days exposure to Bisphenol-A on lipid ratios in Channa punctatus and histopathological alterations in the liver of exposed fish. We observed significant changes in the lipid ratios and concentration dependent hepatic steatosis. This study shows that Bisphenol-A exposure leads to dyslipidemia in fish and may result in symptoms of non-alcoholic fatty liver disease.