Liu, Yijun and Zhang, Hongyang and Tang, Xiaojun and Jiang, Xuejun and Yan, Xiaojuan and Liu, Xizhao and Gong, Jiang and Mew, Kenley and Sun, Hao and Chen, Xiufeng and Zou, Zhen and Chen, Chengzhi and Qiu, Jingfu (2021) Distinct Metagenomic Signatures in the SARS-CoV-2 Infection. Frontiers in Cellular and Infection Microbiology, 11. ISSN 2235-2988
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Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause gastrointestinal symptoms in the patients, but the role of gut microbiota in SARS-CoV-2 infection remains unclear. Thus, in this study, we aim to investigate whether SARS-CoV-2 infection affects the composition and function of gut microbiota. In this study, we demonstrated for the first time that significant shifts in microbiome composition and function were appeared in both SARS-CoV-2-infected asymptomatic and symptomatic cases. The relative abundance of Candidatus_Saccharibacteria was significantly increased, whereas the levels of Fibrobacteres was remarkably reduced in SARS-CoV-2-infected cases. There was one bacterial species, Spirochaetes displayed the difference between patients and asymptomatic cases. On the genus level, Tyzzerella was the key species that remarkably increased in both symptomatic and asymptomatic cases. Analyses of genome annotations further revealed SARS-CoV-2 infection resulted in the significant ‘functional dysbiosis’ of gut microbiota, including metabolic pathway, regulatory pathway and biosynthesis of secondary metabolites etc. We also identified potential metagenomic markers to discriminate SARS-CoV-2-infected symptomatic and asymptomatic cases from healthy controls. These findings together suggest gut microbiota is of possible etiological and diagnostic importance for SARS-CoV-2 infection.
Item Type: | Article |
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Subjects: | Universal Eprints > Biological Science |
Depositing User: | Managing Editor |
Date Deposited: | 15 Dec 2022 10:49 |
Last Modified: | 13 Sep 2023 05:55 |
URI: | http://journal.article2publish.com/id/eprint/240 |