Age Related Serum Antimullerian Hormone Concentrations among Infertile Versus Fertile Women

Aims: Antimullerian hormone (AMH) has been accepted as a marker for the size of the ovarian follicle pool. To interrupt the results of this investigation, age-specific concentrations are needed. The purpose of this study is to compare antimullerian hormone (AMH) concentrations among infertile women ages 22 to 32 years experiencing regular menses with oocytes donors of the same age.

Study Design: Cohort study.

Place and Duration of Study: South Florida Institute for Reproductive Medicine, Miami, Florida and Reproductive Medicine Institute, Evanston, IL. Samples drawn between June 2008 and June 2012.

Methodology: 400 infertile women and 102 oocyte donors aged 22-32 years with a history of regular menses and who were undergoing in vitro fertilization procedures for treatment of infertility had blood drawn for determination of AMH concentrations. Serum AMH was measured by enzyme-linked immunosorbent assay using an AMH ELISA kit (Beckman Coulter, Chaska, MN, USA).

Results: When the mean +2 standard deviations of the serum AMH concentrations among infertile women with regular menses were compared with age-specific oocyte donors, a significant decrease among infertile women was noted at all age groups.

Conclusion: A significant proportion of infertile women have lower than average ovarian reserve, suggesting that serum AMH values reflect follicular supply somewhat independent of age.