Effect of Resveratrol on Some Haematological Parameters of Lead-intoxicated Male Wistar Rats

The aim of this experiment was to investigate the effect of resveratrol on haematological parameters of lead-induced toxicity in male wistar rats. The study employed 36 male wistar rats (150 - 250 g) divided equally into six (6) groups. The first group (negative control) was administered carboxymethylcellulose (CMC) 10 g/L body weight (BW) daily for 19 days. The second group (positive control) was administered lead acetate solution (120 mg/kg BW) daily for 2 weeks. The third group was administered lead acetate solution (120 mg/kg BW) daily for 2 weeks then treated with succimer (10 mg/kg BW) daily for 5 days. The fourth group was administered lead acetate solution (120 mg/kg BW) daily for 2 weeks then treated with resveratrol (200 mg/kg BW) daily for 5 days. The fifth group was administered lead acetate solution (120 mg/kg BW) daily for 2 weeks then treated with resveratrol (400 mg/kg BW) daily for 5 days. The sixth group was pretreated with resveratrol (400 mg/kg BW) daily for 5 days then administered lead acetate solution (120 mg/kg BW) daily for 2 weeks and considered as prophylactic group. All treatments were administered orally by gavage. The animals were euthanized and blood sample were taken for heamatological analysis. In the result, there was significant (P < 0.05) increase in platelet counts in group 5 compared to both negative and positive control groups. No significant (P > 0.05) change was recorded for the other heamatological parameters, when the resveratrol-treated groups were compared to negative and positive control groups. No significant (P > 0.05) change was recorded for the other heamatological parameters, when the resveratrol-treated groups were compared to negative and positive control groups. Thus, the effect of resveratrol in platelet level is dose dependent. This study also observed that all the groups had normal levels of packed cell volume (absence of anemia).