Synthesis and Characterization of PVA-Gelatin Hydrogel Membranes for Controlled Delivery of Captopril

Many biomedical applications including controlled drug delivery systems have been developed based on hydrogel technologies. Different composite hydrogels including synthetic and natural polymers can be produced to controllable systems in drug deliver application.

In this study, poly vinyl alcohol (PVA)-Gelatin hydrogel membranes were prepared by the esterification reaction between hydroxyl groups of PVA and carboxyl groups of Gelatin to deliver Captopril as a model of drug. Captopril was successfully loaded into PVA-Gelatin hydrogel membrane in different ration of Gelatin (10:1, 10:2, 10:3, 10:4, 10:5, 10:6, 10:7, and 10:8). The prepared hydrogel membranes were characterized by Fourier Transforms Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The effects of different process parameters, like percentage of Gelatin, size distribution, swelling behavior and in vitro drug releasing from hydrogel membrane in different phosphate buffer solutions pH (7.1 and 3.9) were studied. The models of kinetics of releasing drug were investigated by using different types of mechanisms (Zero-order, First order, Higuchi’s model and Korsmeyer-Peppas Model).