Evaluation of Laboratory Investigations for Neuropathy in Children and Adolescent with Type I Diabetes Mellitus (TIDM)

Objectives: The study aimed to evaluate different laboratory parameters in children and adolescent with type 1 diabetes mellitus (T1DM) with and without diabetic neuropathy.

Methods: 60 children and adolescents with T1DM was enrolled in this study, they were classified into: 30 cases with T1DM from 2 to 5 years, 30 cases with T1DM for more than 5 years and 30 healthy children matched for age and sex as a control group. Blood samples were obtained from all cases to assess different laboratory investigation including hemoglobin (Hb) level, liver function test (ALT and AST), renal function test (urea and serum creatinine), fasting blood sugar (FBS), 2 h post prandial glucose (2hPP), lipid profile (serum cholesterol and triglycerides) and thyroid function tests.

Results: There was significant value in serum creatinine, serum cholesterol, FBS and 2hPP glucose level between the studied groups.

Conclusion: Patients with DM duration more than five years are associated with impaired renal function, hypercholesteremia and less glycemic control.