Effect of Hydroethanol Leaf Extract of Fleurya Aestuans on Histological and Renal Function Test of an Alloxan Induced Diabetic Wistar Rats

Aim: To examine the effect of Fleurya aestuans extract (FAE) on histological and renal function test (RFT) in an alloxan-induced type 2 diabetes rat model.

Study Design: The experiment was conducted in the department of Human Physiology, Madonna University, Nigeria, between August and September 2020.

Methodology: Thirty-five (35) male Wistar rats were split into seven (7) groups at random. Group 1 was the control group (CG). Group 2 was the negative control group (NCG). Group 3 was the extract group with the lowest dose (LDEG). Group 4 was the medium dose extract group (MDEG). Group 5 was the extract group with the highest dose (HDEG). Positive control group 1 (PCG1) was made up of rats from group 6. Positive control group 2 (PCG2) was made up of rats from Group 7. Rats were given chloroform anesthesia and sacrificed by cutting the jugular vein and blood was collected into heparinized bottles for renal function test.

Results: Fleurya aestuans extract (FAE) at lowest, medium and highest doses given for 30 days resulted in significant reductions in renal electrolyte markers. In diabetic rats treated with FAE, urea and creatinine clearance were likewise declined. Histological experiments were also used to uncover the extract's ameliorative potential structural impacts on renal damage.

Conclusion: We have correctly anticipated that the bioactive elements of FAE may reduce the progression of renopathy using the ALX model. F. aestuans may operate as a possible adjuvant for antidiabetic therapy and should be further researched.